Leveraging Technological Advances to Accelerate Hiv Vaccine Development
نویسنده
چکیده
This white paper discusses current methods for assessing nAb responses and defining genetic determinants of neutralization escape. It also describes the breadth and potency of nAb responses elicited during HIV infection and the primary challenges facing the development of a broadly protective vaccine. Finally, it shares recent efforts to generate new broadly neutralizing monoclonal antibodies (bnAb). The breadth, potency, origin and maturation of these bnAb are the subject of intense investigation, and the features of bnAb are informing novel vaccine designs and strategies today.
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